• Very much affective in Diabetic Foot Ulcer
• Local factors : Such as mechanical, edema, ischemia, foreign bodies and low oxygen tension.
• Systemic factors : Inadequate perfusion, Inflammation, Diabetes, Nutrients, Metabolic diseases, Immuno-suppression, and Smoking.
• Wound Repair versus Regeneration.
• An injury is an interruption of morphology and/or functionality of a given tissue. After injury, structural tissue heals with incomplete or complete regeneration.
• Repair means incomplete regeneration. Or it is a replacement for lost/damaged tissue. Eg: Skin injuries.
• Where as regeneration means replacement of damaged tissue with an exact copy, that the morphology is completely restored. eg: Menstrual cycle.

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